Corneal Disorder - Keratoconus Treatment (Corneal Collagen Crosslinking with Riboflavin)


Keratoconus is a degenerative disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape. It is typically diagnosed in the patient's adolescent years.



Figure : Normal eye & eye with Keratoconus

Symptoms of Keratoconus

People with early keratoconus typically notice

• Minor blurry vision

• A halo around lights and ghosting especially at night

• Photophobia (sensitivity to bright light)

• Eye strain from squinting in order to read

• Headaches and general eye pain

Figure: A simulation of the multiple images seen by a person with keratoconus

Figure: Halos around light

Kerotoconus Treatment

Corneal Collagen Crosslinking with Riboflavin (CXL) is a developing keratoconus treatment.  CXL works by increasing collagen crosslinks which are the natural “anchors” within the cornea. These anchors are responsible for preventing the cornea from bulging out and becoming steep and irregular.


During the corneal crosslinking treatment, riboflavin drops saturate the cornea, which is then activated by ultraviolet light. This process is to increase the amount of collagen cross-linking in the cornea and strengthen the cornea.



Figure : Keratoconus Crosslinking

Figure : Ultraviolet light exposure on the surface of cornea



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